VV speak to a problematic remedial issue for the two patients and doctors. In this investigation, we planned to assess the clinical adequacy and wellbeing of intralesional 5-fu in the treatment of headstrong vv in grown-up patients. It included 60 patients. Subjects and techniques: The patients were isolated into 2 gathering, Group I: As a benchmark group of 10 solid volunteers were biopsied from typical non sun uncovered skin utilizing 4-6mm punch biopsies and Group II: 50 patients with vv exposed to: Group IIa: 15 vv were biopsied before infusion of 5-fu for histological and immunohistochemical examination.Group IIb: 15 vv were biopsied after infusion of 5-fu after 3,4and 7days for histological and immunohistochemical assessment. Infusions were rehashed like clockwork, most extreme for six infusions. Results : caspase-3 was somewhat communicated in completely contemplated instances of typical skin. Caspase-3 was communicated in just 40% of vv which have been biopsied before 5-fu infusion however after infusion the exepression expanded to 86.7%. The previously mentioned findings may reveal insight into the counter apoptotic physiologic part of caspase-3 in typical skin. Caspase-3 over articulation ater 5-fu infusion proposes a likely function of 5-fu on enlistment of apoptosisConclusion: 5-fu is a promising compelling and safe methodology for the treatment of different vv with high freedom rate, gentle and transient unfriendly impacts.