Jaundice is the most widely recognized clinical sign in neonatal medication. In most of cases, jaundice is gentle and transient, coming about because of a youthfulness of the liver's excretory pathway for bilirubin. Thinking about the numerous functions of Vitamin D, lower levels of Vitamin D in these cases might be related with neonatal jaundice. The current examination was embraced to explore the connection between serum nutrient D levels and hyperbilirubinemia in full term youngsters. This case-control study was directed on90 youngsters, enrolled from Neonatal Intensive Care Units [NICUs] of Pediatric Department of Benha University Hospital and Benha Teaching Hospital, in the period from October, 2018 till October, 2019. Neonatalblood tests were gotten and sent to the lab. Profoundly huge abatement of nutrient d levels among patients than controls. Noteworthy negative relationship is between nutrient D levels and serum bilirubin. Nutrient D levels were noteworthy lower in embittered patients than non-embittered controls which may uncover a relationship between circuitous hyperbilirubinemia and serum nutrient D levels. We recommend that more examinations ought to be led including follow up-following 15 days old enough, when jaundice has commonly been settled and before beginning nutrient D supplementation.