Androgenic alopecia influences half of the middle age male occupants, and over 90% of the mature age men. Myostatin might be adequate to upregulate aggravation in essential human sebocytes. We intended to serum myostatin level in patients with androgenetic alopecia to assess its job in the pathogenesis of the malady and its connection to insulin obstruction. In this work, serum Myostatin levels were evaluated in 30 androgenic alopecia patients. Likewise, relationships of Myostatin with the malady seriousness were researched and 20 evidently sound subjects as controls with mateched age and sex. Serum level of Myostatin and HOMA-IR was estimated in the two gatherings utilizing ELISA. HOMA-IR was altogether higher in AGA when contrasted with control gatherings (mean= 4.7 versus 2.7; p < 0.001). No noteworthy distinction was found with respect to FBG and insulin among cases and control gatherings (110.6, versus 82.8, p>0.05; 17.3 versus 13.2; p>0.05). AGA bunch demonstrated essentially higher Myostatin when contrasted with control gathering (mean=397.5 versus 137.9, p < 0.001). Myostatin level and HOMA-IR were proposed to be free indicators of AGA helplessness and severity.We prescribed to evaluate the job of Myostatin in pathogenesis of androgenic alopecia.