Background: Facial scaring has always been challenged to treat and there are many treatments available to decrease the appearance of scars like topical retinoids, chemical peeling, microneedling, dermabrasion, soft tissue fillers, botulinum toxoid injection and laser resurfacing The aim of this study was to evaluate and compare the efficacy of microneedling and fractional CO2 laser in the treatment of post acne scars. A comparative studyOf thirty patients (12 males and 18 females) aged 19 – 36 years with atrophic acne scars were devided into Group (A): treated with Fractional Co2 laser combined with topical platelet rich plasma. Group (B): treated with skin microneedling combined with topical platelet rich plasma. Platelet rich plasma can improve the quality of atrophic acne scars treated with ablative fractional CO2 laser or microneedling and decrease the duration of related side effects including oedema and erythema. Regarding patient's satisfaction grades there was an improvement after both treatment modalities with insignificant differences between both treatment modalities. PRP can improve the quality of atrophic acne scars treated with ablative fractional CO2 laser or microneedling and decrease the duration of laser-related side effects including oedema and erythema.