Although FABP4 is the most commonly known isoform of FABP, no studies have investigated its role in vitiligo. Therefore, our aim was to assess serum FABP4 level in patients with vitiligo.This is a prospective case-control study and was include50 patients suffering from vitilgo. In addition, 30 apparently healthy individuals. Estimation of serum level of FABP4 using Enzyme Linked Immunosorbent assay (ELISA). Serum FABP4 was significantly higher in vitiligo patients when compared to control group (p < 0.001).Higher FABP4 level was significantly associated with overweight. FABP4 showed significant positive correlation with BMI, TC, TG, LDL VASI score, significant negative correlations with HDL in cases. FABP4 could be used to predict metabolic syndrome and cardiovascular disease development in vitiligo patients.. In addition, lipid profile, BMI and VASI of the vitiligo are significantly correlated with FABP4.