Ongoing examinations recommend that the dysbiosis focusing on predominantly C. acnes along with the actuation of the natural invulnerability may prompt the constant incendiary reaction in skin break out vulgaris. Myostatin might be adequate to upregulate irritation in essential human sebocytes. We intended to assess serum myostatin level in patients with skin break out vulgaris to assess its job in AV pathogenesis and its connection to insulin opposition. In this work, serum Myostatin levels were evaluated in 30 skin inflammation vulgaris patients. Additionally, connections of Myostatin with the sickness seriousness were researched and 20 obviously sound subjects as controls with mateched age and sex.Serum level of Myostatin and HOMA-IR were estimated in the two gatherings utilizing ELISA. HOMA-IR was essentially higher in AV when contrasted with control gatherings (p=0.001).No noteworthy distinction was found in regards to FBG and insulin among cases and control gatherings (p>0.05 for both). AV bunch demonstrated altogether higher Myostatin when contrasted with control gathering (mean=507.3 versus 238.8, p < 0.001). Myostatin level and HOMA-IR were proposed to be autonomous indicators of AV helplessness and seriousness. This propose a likely job of serum myostatin level as a hazard factor of IR and its related issues. We prescribed to evaluate the job of Myostatin in pathogenesis of skin break out vulgaris.