Four elements are accepted to assume a key function in the improvement of skin break out sores: abundance sebum creation, upset keratinization inside the follicle, colonization of the pilosebaceous conduit by Propionibacterium acnes, and the arrival of incendiary middle people into the skin. Point: Evaluation of serum levels of sirtuin1 (SIRT1) in skin inflammation vulgaris patients. Patients and Methods: Serum SIRT1 focuses were estimated in 30 patients with AV and 15 solid controls utilizing chemical connected immunosorbent examine (ELISA). Results: Serum SIRT1 levels are diminished in patients with serious AV contrasted with patients with gentle, moderate and controls. End: Decreased serum SIRT1 presumably mirror the part of SIRT1 in the pathogenesis of AV.