Unsaturated fat restricting proteins (FABP) are a gathering of cytosolic lipid transporters which facilitate incendiary and metabolic pathways in cells. The point of this momentum study was to gauge serum levels of FABP4 in patients with skin break out vulgaris and to survey connection between's its level and seriousness of the malady. This investigation included 50 patients with mellow (17 patients), moderate (17 patients) and extreme (16 patients) skin break out vulgaris as indicated by Global Acne Grading System All contemplated patients were exposed to history taking, dermatological assessment and estimation of serum FABP4. The aftereffects of this case–control study showed that the mean serum levels of FABP4 was essentially higher in AV patients. Mean FABP4 levels demonstrated non-noteworthy distinction between various types of severity.FABP4 appears to have a fundamental function in the etiopathogenesis of this fiery skin malady, So it is viewed as a promising objective in treating AV and other provocative infections.