Erectile dysfunction [ED] is persistent inability to achieve or maintain rigid penile erection sufficient for satisfactory sexual performance. It is a typical clinical element that influences basically men more seasoned than 40 years. Away from the psychogenic reasons for ED, numerous natural factors, for example, diabetes mellitus, hypertension, heftiness and smoking have been connected to the improvement of ED which is viewed as of vascular beginning in by far most of the patients. Microfibrillar-related protein 4 [MFAP4] is an extracellular network protein which legitimately ties to collagen, elastin and fibrillin. It is restricted to extracellular network protein strands in courses all through the body. MFAP4 has an immediate job in vascular occlusive redesigning with deferred neointimal development. The point of study is to assess MFAP4 in serum of patients with ED. We decided the degree of mfap4 in the serum by means of protein connected immunosorbent test [ELISA]. serum mfap4 levels in 50 ED patients were fundamentally higher than in 30 solid volunteers [p >0.001]. this outcome exhibited solid relationship among ED and serum level of mfap4, being expanded in ED.