Acne vulgaris is a disease of pilosebaceous unit that is most commonly seen during adolescence . Increasing pubertal age, seborrhea, the premenstrual phase, mental stress, and sweet and oily foods were recognized as risk factors for moderate to severe acne. Also gender, spicy foods, and smoking were not associated with acne severity This case-control study included 50 participants; 30 patients suffering from moderate and severe acne vulgaris, in addition to 20 apparently healthy, age and sex matched individuals . Present history including age of onset of acne, disease duration, course of the disease and risk factors (diet, sun exposure , smoking, stress) family histories were obtained from all patients. logistic regression analysis was conducted for prediction of acne vulgaris development, using age, gender, smoking, risk factors,. Positive FH, smoking, higher frequency sun exposure, high caloric diet, excess stress, were associated with risk of acne vulgaris occurrence in univariable analysis. Estimation of risk factors including Positive FH, smoking, higher frequency sun exposure, high caloric diet, excess stress are important in prediction and management of acne vulgaris .