Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU) . In 2015, acne was estimated to affect 633 million people globally, making it the eighth most normal infection worldwide.Few contemplates revealed that huge numbers of skin break out patients had worthy helpful reaction with a decrease of skin break out sores with joined utilization of effective retinol and oral lactoferrin in mellow and moderate skin inflammation. We planned to assess the serum level of lactoferrin in patients with skin break out vulgaris and connect its level with a seriousness of skin break out. Strategies: An imminent case-control interventional study included 90 members devided to Group A: 70 patients clinically analyzed as skin break out vulgaris. Gathering B : included 20 clearly solid (control gathering). Serum lactoferrin had been estimated in the two patients and control subjects . Results: there was an exceptionally factually huge negative connection between's illness length and serum lactoferrin level among case gathering. there was a critical connection among lactoferrin and Acne seriousness, this connection can be utilized to anticipate the seriousness of the infection, at cut off estimation of lactoferrin >174.2 with great prescient separate among gentle and extreme Acne, AUC=0.979 Conclusion:. This clinical examination exhibited that serum LF level is straightforwardly identified with serious skin break out in the intense stages as opposed to mellow interminable skin break out. Accordingly, it could be of prognostic incentive as a marker of seriousness and could be then utilized for remedial arranging and development.