LC is the gold standard treatment for gallstones. Ultrasonic scalpel, which causes three synergically acting effects: cavitation, coaptation / coagulation and cutting. to Compare between laparoscopic cholecystectomy utilizing energy sealing devices (clipless) and conventional laparoscopic cholecystectomy as regard operative time, pain, infection, bile leakage ,early post-operative recovery , hospital stay ,the need for drain …. etc. This was a prospective study, which was performed at the General Surgery Department of Benha University Hospital after approval by the Benha Faculty of Medicine Research Ethical Committee, and all patients signed informed consent to be included in this study.As far as our analysis in Group A was concerned, mean hospital stay (in days) was (2.21) while mean hospital stay (in days) was (2.24) in Group B, there is no statistically significant difference in hospital stay between the two groups. In Group A: postoperative infection occurred in one case, in Group B postoperative infection occurred in 2 cases, and in both groups there was no postoperative bile leakage. The energy sealing system offers full hemobiliar stasis to all patients and is a healthier alternative to traditional cystic duct and artery video. It has a shorter processing time, decreased blood loss and decreased transfer rate for open cholecystectomy.