Foundation and destinations .Acute kidney injury (AKI) is related with unfavorable results, particularly in youngsters admitted to the pediatric emergency unit). AKI is a typical inconvenience related with longer medical clinic length of remain, increment of dismalness and mortality in kids who require concentrated consideration. Around then the RIFLE (Risk Injury Failure Loss End stage) score fills in as an appropriate characterization of AKI when defined by clinical seriousness. This investigation done to decide the frequency, etiology of AKI, pointer of casualty and transient result of AKI in fundamentally sick youngsters. Subjects and Methods:This imminent examination incorporate 200critically sick patients with at least one framework disappointment admitted to the PICU during the time of study. Consideration measures was successive patients admitted to the PICU. Avoidance rules - was Patients with known interminable kidney infection stage 5 (assessed glomerular filtration rate < 15 ml/min/1.73 m2). They were screened for AKI, characterized by the pRIFLE measures. The patients with AKI were followed-up until release/demise. Their clinical and biochemical information were recorded. All patients were exposed to: full history including the etiology of PICU confirmation and reasons for intense kidney injury. Nitty gritty fundamental assessment, including indispensable signs, cardiovascular and different frameworks. Fundamentally sick patients were characterized on the off chance that at least one of the rules which present during a 24-hr period as per organ brokenness standards . Research center Investigations were incorporated finished blood check, C-receptive protein, blood vessel blood gases, corrosive base status, blood urea, serum creatinine , electrolytes, blood glucose, serum bilirubin level, cerebrospinal liquid examination and culture for bacteriologic investigations (blood, endotracheal suction, and cerebrospinal fluid)when required. results: The occurrence of AKI among 200 patients screened was 54 (27%). The basic etiologies in AKI bunch were contaminations, 28 (51.8%), stun 18(33.3%), intense glomerulonephritis 2 (3.7%), cardiovascular disappointments 4(7.4%) and status epilepticus 2(3.7%). Among diseases, pneumonia and septicemia comprised 78.5%, meningoencephalitis represented 21.5% and 6 (11) % of patients required dialysis. In general mortality in AKI bunch was 37%. On strategic relapse examination, necessity of mechanical ventilation was a free indicator of casualty in AKI gathering.