Grid metalloproteinases (MMPs) and their particular inhibitors (tissue inhibitors of metalloproteinases, TIMPs) are fundamental for the redesigning of the extracellular framework, and incendiary infections, for example, skin inflammation. Skin break out vulgaris is an incessant incendiary illness that influences most of the populace. It is described by comedones, pustules, and papules. In this examination, it was expected to research the possible relationship between MMP-1 quality polymorphism and the hazard for skin inflammation advancement. Polymorphism of MMP-1 Gene was estimated in 60 patients with skin break out vulgaris and 40 solid controls utilizing polymerase chain response (PCR). A noteworthy connection between MMP-1 (1607 A/G) polymorphism and skin inflammation vulgaris was recognized.