Psoriasis is a chronic, immune-mediated, inflammatory disease of the skin. It is a multifactorial malady with hereditary foundation activated by enviromental factors and immunological middle people. Numerous Epidemiologic examinations proposed that patients with psoriasis are at expanded danger of cardiovascular disease.To assess serum salusin beta level in psoriatic patients. In this relative case-control study, 50 psoriatic patients (case gathering) and 30 age-and sexual orientation coordinated solid people filling in as a benchmark group, were chosen from the outpatients' facilities of the Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Benha University, during the period from October, 2018 to May, 2019. This investigation found that the serum salusin-β levels were signifcantly higher in psoriasis patients contrasted with control group.This study found that the serum salusin-β levels were signifcantly higher in psoriasis patients contrasted with control gathering.