Sepsis is a common and serious neonatal problem with high morbidity and mortality particularly in resource limited communities. Broad examination endeavors have yielded numerous biomarkers which are conceivably helpful, for conclusion of sepsis as well as for forecast of its result. to examine the analytic job of RDW in 50 of full term children with sepsis and to assess its job in clinical result of neonatal sepsis. This investigation was completed on 100 youngsters conceded in neonatal emergency unit of Benha University Hospital and Benha Teaching Hospital during the period from (December 2018 to February 2020). Moral Research Committee Approval and composed assents were acquired from guardians of the youngsters 50 neonatal sepsis cases and 50 typical controls. Consideration standards: age from 1-28 days and had discoveries of sepsis either clinical or lab. Youngsters were exposed to: History taking, clinical assessment for signs of sepsis. Complete blood tally, C-receptive protein, Blood culture and affectability and assurance of RDW % were done to all children. Mean RDW % was higher among cases than controls (16.7 ±1.6 and 12.9 ±1.4respectively) (P < 0.001), then hemoglobin (HB) was lower in cases than controls P=0.542. WBCs were higher among cases contrasted with control (P <0.001). CRP was typical in all controls, and was higher in all cases. RDW % was higher in serious sepsis than mellow (19.2 ± 1.8& 16.4 ± 0.5 separately) (P < 0. 001). RDW % can fill in as a symptomatic marker and anticipate sepsis seriousness as a noteworthy distinction was found between its incentive among youngsters with mellow sepsis and extreme sepsis.