Androgenetic alopecia (AGA) which is also known as androgenic alopecia or male pattern baldness, is the most common type of progressive hair loss. Male androgenetic alopecia (MAA) is the most common form of hair loss in men, affecting 30-50% of men by age 50. Male androgenetic alopecia (MAA) occurs in a highly reproducible pattern, preferentially affecting the temples, vertex and mid frontal scalp.To estimate the Serum Amyloid A3 (SAA3) in young male patients with AGA and studying the relationship between the level of SAA3 and atherosclerosis. The investigation was done after endorsement by the Ethics advisory group on Research at Faculty of Medicine, Benha University. A composed educated assent was acquired from every member. This examination was a cross sectional case similar investigation. All patients chose from Outpatient Clinic of Dermatology, Venerology and Andrology Department of Benha University Hospitals. This examination was begun at January 2019 to June 2019.We found that the patients with grade III and IV androgenetic alopecia with family ancestry of heart illnesses and raised lipid profile levels had critical height of serum amyloid A3 than different gatherings. Male patients underneath age of 30 years with AGA exceptionally grade III, IV had raised SAA3 and have more dangers to create blood vessel atherosclerotic illness later on than the people without AGA at a similar age gathering.