Psychological issues, particularly anxiety and depression, have received growing attention in chronic disease patients and should not be overlooked when assessing patient's quality of life (QoL). This is a significant objective in the clinical administration of an incessant irreversible illnesses, for example, ceaseless obstructive pneumonic ailment (COPD) A case control investigation of incorporate 100 patients with cutting edge constant respiratory maladies including serious persevering asthma, extreme COPD, broad bronchiectasis and interstitial lung infections. Patients were chosen arbitrarily from those going to inpatient ward and outpatient center at Chest office in Benha University Hospitals. 20 age and sex coordinated evidently ordinary subjects will be incorporated as negative controls just as 20 mellow ceaseless respiratory issue as positive controls.There was high huge FEV1 was in negative control than positive control than the contemplated gathering, Anxiety and wretchedness more in female than guys .Also nonappearance of uneasiness was fundamentally high in negative control than in positive control than in study gathering. profoundly noteworthy melancholy scores in the examination bunches than control group.no critical. the Prevalence of tension and wretchedness more in patients without respiratory disappointment than those have respiratory failure.Prevalence of uneasiness and melancholy progressively regular in ceaseless respiratory diseases.Many factors influence predominance and seriousness of both nervousness and despondency as gender,FEV1 PAP, dyspnea.