Common warts (verruca vulgaris) are caused by human papilloma virus (HPV). They are one of the most common problems in dermatology but no particular therapy has demonstrated complete efficacy. Treatment options include cryotherapy, surgical excision, bleomycin and various lasers. Each mode of therapy has its own complications ,failure rate and may also develop a new lesion in anew area after successful treatment of previous one. The point of this work was to assess the security and viability of intralesional Vitamin D3 for the treatment of verruca vulgaris, distinguish histopathological changes in verruca vulgaris after infusion of nutrient D3 and look at between immunohistochemical articulation of involucrin when the infusion. This examination was performed on 20 patients with different verruca vulgaris infused with nutrient D3 and ten obvious sound people as control gathering. 40% and 20% of the rewarded patients demonstrated total reaction in the first and the second infused moles, individually. Incomplete reaction in 35% and 55% of the first and the second infused moles, separately. As respects the reaction of the non-infused mole, 66.7% demonstrated fractional reaction. The histopathological changes in moles after infusion of nutrient D3 were diminishing in the thickness of epidermis and decrease in incendiary cells in dermis. There are histopathological changes after infusion of nutrient D3 in verruca vulgaris incorporating stamped diminishing in epidermal thickness and diminishing of incendiary cells in the dermis. In verruca vulgaris, Involucrin articulation is higher after infusion of nutrient D3.