Two‐dimensional speckle strain (2D STE) echocardiography can aid in the prognosis of acute myocardial infarction (AMI) and chronic coronary artery disease (CAD). the aim of the present study was to determine the possibility of using of two-dimensional speckle tracking echocardiography to predict cardiac events comparing of patients with acute myocardial infarction versus chronic coronary artery disease. this was a prospective study includes two hundred patients (20-70 years old) in two groups were selected from national heart institute and El Sahel hospitals first group one hundred of patients with a diagnosis of first attack of acute myocardial infarction (STEMI or NSTEMI) and the other group one hundred of patients with known chronic CAD who presented for clinical checkup at the outpatient department . The duration of the study ranged from 6-12 months. as regard strain parameters in patients with first acute MI; there was high significant difference between cases with cardiac event and those without as regard GLS epi %, GLS total wall, % and GCS endo,%, also there was significant difference between cases with cardiac event and those without as regard GLS endo, (%),GCS epi,% and GCS total wall,%., and there was highly statistical difference between chronic coronary heart diseases cases with cardiac event and those without as regard conventional echocardiography and strain parameters. Global strain parameters by 2D STE may be useful for the prediction of cardiac events in patients with CAD but add no supplemental information to baseline characteristic and ejection fraction in patients with AMI.