Growth differentiation factor (GDF)-15 was identified as a factor secreted by activated macrophages which plays an important role in cell growth, signal transduction, and apoptosis regulation . The aim of this study is to: Correlate serum level of growth differentiation factor 15(GDF- 15) with disease activity and severity parameters in rheumatoid arthritis patient. This study will include thirty rheumatoid arthritis (RA) patients fulfilling the American College of Rheumatology/European League Against stiffness (ACR/EULAR) criteria to the analysis from claiming RA recruited from Rheumatology, restoration physical and drug outpatient facility What's more inpatient division about Benha school doctor's facilities. Also, twenty solid persons sex Also agdistis matched of the patients were selected in this study as An control bunch. Every last one of patients and controls were subjected with full history taking, full clinical examination, research center investigations that included cbc ,ESR. Crp. Rf , serum -Growth diferentation variable 15(GDF15) levels, those malady movement score -28 (DAS28)was used to assess the infection movement for rheumatiod joint inflammation. The wellbeing evaluation quaestionnaire (HAQ) might have been used to assess those utilitarian status. Those level of joint harm might have been evaluated as stated by Larsen strategy. Clinched alongside our ponder GDF15 levels were fundamentally higher to rheumatiod joint inflammation patients The point when contrasted with those control (p < 0. 05). Accordig to pearsons corrrelation ,serum GDF15 levels were postivitly associated with esr level,morning firmness. DAS28 score. Youthful joint. Swollen joint,and x beam "around body of evidence one assembly. GDF15 might assume a part in the pathway from claiming infection action. Joint inclusion large amounts from claiming GDF-15 were connected with sickness activity, level of ESR, morning stiffness, delicate joint count,.