Type 2 diabetes mellitus (T2DM) is one of the most common diseases with a high incidence and prevalence throughout the world. The prevalence of type 2 diabetes is rising at an alarming rate due to increase in life expectancy, obesity, physical inactivity and adoption of sedentary lifestyles. This study aimed to investigate the association of APOA1 polymorphism (-75 G/A and +83 C/T) with dyslipidemias ,to assess the association of Apolipoprotein A1 gene polymorphism and coronary artery disease in type 2 diabetic patients and also aimed to study the susceptability to CAD among Egyptian patients with T2DM. The subjects of the study were enrolled as thirty six (36) as acontrol group, thirty six (36) known to be T2DM without any cardiovascular complications and thirty six (36) known to be T2DM with coronary artery disease. The greater part about them were subjected with careful historical backdrop taking, finish clinical examination, research center investigations including (FPS,2hr postprandial blood glucose, HbA1C Furthermore finish lipid profile) What's more coronary angiograghy to diabetic patients confounded with coronary supply route infection. We discovered that, no critical Contrast of the circulation for each genotype or alleles the middle of control assembly and diabetic one assembly Be that as both (CT & TT) genotypes and t alleles were a greater amount dispersed in the confounded diabetic bunch thereabouts we camwood Think as of them as a hazard figure to lowlife Previously, kind 2 diabetic patients. Both ga Furthermore AA genotypes Also An allele of APOA1 G-75A were altogether higher done controls over both T2DM Assemblies (without or for CAD).