Liver biopsy is the most accurate examination method to evaluate liver fibrosis stage but is invasive. Non-invasive biomarkers of disease progression are therefore needed. Assess the role of serum Mac-2 Binding Protein Glycan Isomer levels in diagnosis of liver fibrosis in children with chronic liver disease. This examine might have been an instance controlled ponder that might have been directed with respect to an aggregate number from claiming 160 Youngsters about both sexes. 100 know youngsters (case group) gathered starting with outpatient pediatric hepatology facility of Benha school doctor's facilities. Sixty Obviously sound kids (control group) matched the tolerant gathering done period Furthermore sex. Every one kids subjected on full historical backdrop taking, physical examination and research center Investigations, liver biopsy Also serum M2BPGI level Eventually Tom's perusing elisa. There might have been measurable noteworthy Contrast between contemplated gatherings in regards serum M2BPGI Similarly as it might have been raised over constant liver infection gathering. There were measurable noteworthy contrasts the middle of serum level for M2BPGI What's more fibrosis index, histological action list Similarly as it expands with build fibrosis list Furthermore hepatitis action list. The best cut off worth about serum M2BPGI might have been 1. 06 ng/ml for identification from claiming promptly fibrosis phase for affectability 87. 1%, specificity half What's more range under those bend may be 0. 823 same time the best cut off serum M2BPGI for identification of propelled fibrosis might have been 5. 55 ng/ml with affectability 97. 8%, specificity 92. 7 What's more territory under those bend is 0. 987. M2BPGI might a chance to be An novel non-invasive biomarker for liver fibrosis carried out with respect to egyptian know youngsters with liver infection.