Adolescence is a critical transitional period that includes the biological changes of puberty and the need to negotiate key developmental tasks, such as increasing independence and normative experimentation. It is an important developmental period for the onset of substance-use and misuse which has been shown by epidemiological studies across the life span, to find out the demographic data of studied adolescents and the distribution according to the substance abused and to assess the factors associating suicidality and adolescents with substance use disorders, The example comprised of 100 young people analyzed as having substance use issue were remembered for the investigation, and Diagnosis has been done by the Diagnostic and Statistical Manual of Mental issue, fifth release (DSM-V).. All patients were exposed to A semi organized meeting including segment dispersion, kind of medication, individual, present, past, instructive and family ancestry , Clinical assessment including a psychological state assessment , Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) Suicide Probability Scale (SPS) and Teen Addiction Severity Index (T-ASI), About 75% of the contemplated patients detailed manufactured medications as the fundamental substance dependent. Seven patients just adhered to one substance. The biggest level of them detailed utilization of numerous medications (93%).Moreover biggest level of the examined patients had important family ancestry for compulsion (72%), while just 13% of them had family ancestry of mental issue Synthetic medications are the fundamental substance dependent by around 75% of the contemplated young people. Catchphrase: Suicidality ; Adolescents ; Substance use issue.