Necrotizing enterocolitis (NEC) continues to be a leading cause of morbidity and mortality in premature infants.Premature infants may be at risk of NEC due to developmental deficiency of transforming growth factor Beta-1 level in the intestine, which is further accentuated during NEC. No significant differences in the incidence of NEC are noticed between male and female patients. TGF- β1 is an important marker for diagnosis and prognosis of necrotizing enterocolitis in extremely low birthweight infants and the aim of this work was to evaluate the diagnostic and prognostic value of transforming growth factor Beta-1 (TGF- β1) Level On necrotizing enterocolitis for greatly low birthweight babies. This might have been an instance - regulated study that incorporated 50 greatly low birthweight newely destined babies diagnosed Likewise necrotizing enterocolitis clinically and arranged as stated by altered Bell's arranging criteria and 25 greatly low birthweight newely conceived babies without nec clinched alongside nicu of from june 2017 should june 2018. We established that the mean conception weight clinched alongside nec aggregation might have been 1. 61 ± 0. 35 (kg) Furthermore in control gathering might have been 1. 65 ± 0. 35 ( kg ) with male predominance. TGF- β1 level ≤ 864. 3 at onset about manifestations might altogether ( p = 0. 004 ) foresee nec Also TGF- β1 level ≥ 964. 7 after 7 times from claiming onset for manifestations could essentially ( p = 0. 011 ) anticipate seriousness of nec.