Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units. It is a pleomorphic disorder with multifactorial pathogenesis, affects virtually all individuals at least once. PTX3 represent a rapid biomarker for primary local activation of innate immunity and inflammation. to assess serum level of pentraxin 3 in patients with acne vulgaris. This instance control examine might have been directed on 55 patients anguish from av (Group An) What's more 30 Obviously solid people for matched period Furthermore sex as An control assembly (Group B). Constantly on patients were subjected to full history taking, complete clinical examination Furthermore serum level about Pentraxin3 (PTX3). The patients imply period might have been 21 years, they were 20 guys (36. 4%) Furthermore 35 females (63. 6%). Twenty four patients required sudden passing onset (43. 6%),While 56. 4% required gradual onset. Same time 38 (69. 1%) patients required progressive course. Imply span of malady for concentrated on patients might have been 4. 7 years, face might have been influenced altogether cases55(100%) patients taken after Toward over 25 (45. 5%)patients What's more midsection 12 (21. 8%) patients. Skin break out seriousness might have been evaluated On the whole examined cases; gentle situations spoken to 29. 1%; moderate situations spoke to 38. 2% same time extreme level might have been exhibit Previously, 32. 7%. Skin inflammation vulgaris patients indicated essentially higher fixation of Pentraxin 3 (Ptx 3) The point when contrasted with control bunch (P. 0. 011). Skin inflammation vulgaris patients indicated essentially higher centralization for Pentraxin 3.