Toxoplasma gondii parasite is one of the world's most common parasites which is an intracellular parasite. The aim of this work is to investigate the effect of nitrofurantoin given at a dose of 100mg/kg(2mg for each mouse) , spiramycin given at a dose of 200mg/k.g (4mg for each mouse) and a combination of both(4 days post infection for 2 weeks) on the brain cyst count of infected mice (54 laboratory-bred Swiss albino mice). Mice were contaminated for 10 cysts for Toxoplasma gondii (ME 49 strain). Five aggregations for mice were utilized within those study,three bunches for them accepted medicines and the different two were ordinary Furthermore contaminated non treated aggregations. One bunch approached with spiramycin,other approached for nitrofurantoin, and the final one approached for the blending for both. The mice were sacrified then afterward 8 weeks. The blending for both pills made 4 days post spoiling for two weeks brought about critical diminishment in the mind growth check (78) with diminishment rate( 85. 2% ) contrasted with different gatherings. This goal that nitrofurantoin Might be an satisfactory antitoxoplasmic medication regardless same time its mix with spiramycin provided for those best result.