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135452

Serum Heat Shock Protein 90 in Diagnosis of Biliary Atresia

Article

Last updated: 05 Jan 2025

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Abstract

Punctual ID number for biliary atresia (BA) may be key. Dependable non-invasive instruments for finding are needing. High temperature stun protein 90 an adenosine triphosphate subordinate sub-atomic chaperone that is included to hepatobiliary conversion. Those available investigation plans should assess its part in analysis from claiming ba. What added up to 90 babies were included in the examine. They comprised 30 babies with BA, 30 babies for non-BA cholestasis Also 30 Obviously period Also sex matched solid babies who were selected Concerning illustration controls. Babies diagnosed for ba alternately different non-BA cholestasis were incorporated in the consider on the foundation from claiming clinical pattern, cholangiogram, Also histological discoveries. After full historical backdrop taking What's more careful clinical examination, the finding for ba might have been affirmed Eventually Tom's perusing intraoperative cholangiography. Other investigations incorporated downright Also immediate bilirubin, aggregate proteins, albumin, ALT, AST, ALP, GGT, prothrombin time, worldwide normalized proportion (INR), finish blood count, light race antibodies, ultrasonography examination Furthermore liver biopsy. Serum levels about HSP90 might have been evaluated utilizing elisa method. It might have been discovered that ba patients needed essentially higher HSP90 levels when compared with non-BA patients Also sound controls (BA: 671. 0 (309. 7-803. 0, non-BA: 151. 5 (120. 5-172. 7), controls: 55. 0 (26. 5-68. 7) pg/ml, p < 0. 001). In An cut-off from claiming 195. 5 pg/ml, HSP90 indicated phenomenal affectability and specificity to recognizing ba starting with non-BA patients (AUC: 0. 982, p

DOI

10.21608/bjas.2020.135452

Keywords

Neonatal cholestasis, biliary atresia, Heat shock protein 90

Authors

First Name

M.S.

Last Name

Eldfrawy

MiddleName

-

Affiliation

Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

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Orcid

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First Name

H.A.

Last Name

Elaraby

MiddleName

-

Affiliation

Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

-

Orcid

-

First Name

S.A.

Last Name

Elgendy

MiddleName

-

Affiliation

Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

-

Orcid

-

First Name

H.E.

Last Name

Elazawy

MiddleName

-

Affiliation

Biochemistry Dept., Faculty of Medicine, Menoufia Univ., Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Sh.M.

Last Name

Azab

MiddleName

-

Affiliation

Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

-

City

-

Orcid

-

Volume

5

Article Issue

Issue 2 part (1)

Related Issue

20198

Issue Date

2020-02-01

Receive Date

2020-01-04

Publish Date

2020-02-01

Page Start

97

Page End

101

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_135452.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=135452

Order

14

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Serum Heat Shock Protein 90 in Diagnosis of Biliary Atresia

Details

Type

Article

Created At

23 Jan 2023