The purpose of this study was to evaluate the role of pregnancy-associated plasma protein-A and uterine artery Doppler in early detection of preeclampsia. Subjects of this prospective cohort study included (120) pregnant women with viable singleton pregnancies in the first trimester between (11- 13+6 ) weeks of gestation, were recruited during the period from March 2018 to January 2020 and who came for ante natal clinic, in the Department of Obstetrics and Gynecology at Benha University Hospital. Consideration criteria were Pregnant ladies going to antenatal forethought toward Benha outpatient facility for singleton feasible pregnancy In 11-13+6 weeks gestation (Fetal crown-rump length (CRL) might have been 45-84 mm for typical fetal morphology). For each tolerant we measure uterine corridor doppler and pregnancy cohorted plasma protein and the outcomes were Pregnancy copartnered plasma protein (PAPP-A) indicated profoundly noteworthy Contrast between instances for preeclampsia What's more instances that don't create preeclampsia (p quality 0. 004) same time both uterine corridor pulstality list (UTPI) Furthermore uterine corridor imperviousness list (UTRI ) are stastically critical. We closed that mix for uterine corridor stream indices Also pregnancy connected plasma protein from the beginning trimester needed progressed early identification about preeclampsia.