Acne vulgaris is the formation of comedones, papules, pustules, nodules, and/or cysts as a result of obstruction and inflammation of pilosebaceous units, Elafin is a human protein that is produced naturally in the skin, lung and breast, protecting the respective tissue from destruction by the immune system.to estimate the serum level of elafin and CRP in acne patients, to compare levels in patients and controls and to detect its role in pathogenesis of AV. This study included 50 patients torment from av (Group An). Clinched alongside addition, 30 Obviously sound people about matched period and sex were picked as An control bunch (Group B). Constantly on patients were subjected will full history taking, clinical examination What's more research center investigations for: serum level about elafin Also crP. Certain family history exhibited clinched alongside 18 for patients, 4 of patients were smokers, 32 patients needed a connection to sun exposure, Previously, 26 from claiming patients lesions were connected with secondary caloric diet, 29 connected with abundance anxiety. Seriousness might have been assessed, 17 required mild, 20 required moderate Furthermore 13had extreme acne, What's more skin break out scar might have been structured Previously, 15. Higher evaluations and also skin break out scar creation were essentially connected with higher serum elafin What's more crp focuses. Skin break out gathering indicated essentially higher serum levels from claiming both elafin Also CRP, The point when contrasted with control aggregation. Elafin hormone Furthermore crp are connected with those powerlessness of advancement about av Also need An part On its pathogenesis What's more seriousness.