Preterm birth is a leading cause of perinatal mortality and morbidity and has adverse long –term consequences for
the child health. The vast majority of morbidity and mortality relates to early delivery before 32 weeks. to evaluate
whether the prophylactic administration of vaginal progesterone would reduce the preterm birth rate in singleton highrisk
pregnancies. This prospective,observational study included 100 cases of high risk pregnant women admitted to
Obstetrics and Gynaecology Departments in Benha University and El Bagour General Hospital. Participants were
divided into two groups: a Study Group including 50 pregnant women under treatment by prophylactic progesterone
vaginal suppository [prontogest 400mg vaginal suppository from period of 28 – 34 weeks and a Control Group:-
including 50 pregnant women not treated by progesterone vaginal suppository. The incidence of preterm deliveries in
the study group was significantly lower than that of the control group [38% versus 56%], the postnatal morbidity was
significantly lower [6% versus 15%] while the postnatal mortality was significantly different. Our results indicate that
the progesterone therapy significantly reduces the incidence of preterm delivery. The study concludes that vaginal
progesterone reduces the risk of PTB,NICU admission,RDS in singleton high-risk pregnancies.