Psoriasis is a lifelong chronic inflammatory disease of the skin with an estimated prevalence of 1-3% in the community. Endoglin (Eng; CD105) is an auxiliary receptor for the transforming growth factor β (TGF-β) family of proteins and has been shown to be essential for angiogenesis and is predominantly expressed on proliferating endothelial cells.Its mutation leads to heredirary hemorrhagic telengectasia. The aim of this study is to evaluate the serum level of endoglin in patients with psoriasis and its correlation with the disease severity. Endoglin level might have been assessed in the serum from claiming 54 patients and 30 control subjects utilizing elisa. Information examination might have been conveyed crazy for the whole companion. Facts were performed utilizing programming. Comes about from claiming this ponder demonstrated that those intend serum level from claiming endoglin might have been higher On psoriatic patients over control one assembly for a huge quality. Our discoveries recommend that, there may be a part of endoglin in the pathophysiology Furthermore seriousness of psoriasis.