Alopecia areata (aa) is a common type of hair loss. It is an autoimmune disease with a variable, typically relapsing or remitting, course that can be persistent-especially when hair loss is extensive. Three major phenotypic variants of the disease are patchy-type aa, alopecia universalis and alopecia totalis. The aim of the present study was to assess the relation between TAP1(rs1057141) gene polymorphism and alopecia areata risk and its clinical criteria. This study was carried out on 100 patients suffering from Alopecia Areata and 100 apparently healthy individuals of matched age and sex as a control group. Patients were recruited from the outpatient clinic of Dermatology and Andrology Department of Benha University Hospitals during the period from August 2018 to January 2019. There was insignificant difference in TAP1 (rs1057141) genotypes in both studied groups. TAP1 (rs1057141) gene polymorphism does not have a role in alopecia areata development.