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135746

Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients

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Last updated: 28 Dec 2024

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Abstract

Alopecia areata (AA) is a common disease with an incidence of 2-3% among the dermatoses and 0.1% in the population at large. This disorder occurs in both sexes, at all ages, and is characterized by the sudden appearance of areas of hair loss on the scalp and other hair bearing areas. Various factors, including immunologic and endocrine abnormalities, genetic factors, infections, and psychological/ psychiatric disturbances, have been claimed to play a role in its etiopathogenesis. The aim of this study is to investigate the association between DEFB1 polymorphism and AA pathogenesis. This study was conducted on fifty patients with alopecia areata (Group A) and fifty age and sex matched apparently healthy subjects as a control group (Group B). Patients were selected from the Dermatology outpatient clinic of Benha University Hospital. Linear regression analysis was conducted for prediction of more severe AA; using age, gender, family history, AID, previous episodes, previous treatment, and rs1800972 genotypes as covariates. Rs1800972 (CG+GG) were considered as predictor of more severe AA (p < 0.001). Our study results support the associations of susceptibility with AA among patients with the DEFB1 rs1800972 genotypes. It appears that DEFB1 gene polymorphisms may modulate AA risk. So, CG, GG, genotypes and G allele were considered as predictor of AA susceptibility and severity.

DOI

10.21608/bjas.2020.135746

Keywords

AA, aid, DEFB1 and CG

Authors

First Name

A.A.

Last Name

Ibrahim

MiddleName

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Affiliation

Dermatology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

N.F.

Last Name

Alhusseiny

MiddleName

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Affiliation

Medical Biochemistry and Molecular Biology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

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Orcid

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First Name

A.I.

Last Name

Mustafa

MiddleName

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Affiliation

Dermatology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

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Orcid

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First Name

A.S.

Last Name

Yousef

MiddleName

-

Affiliation

Dermatology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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City

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Orcid

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Volume

5

Article Issue

Issue 1 part (1)

Related Issue

20062

Issue Date

2020-01-01

Receive Date

2020-01-05

Publish Date

2020-01-01

Page Start

53

Page End

56

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_135746.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=135746

Order

7

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Association of Human Beta – Defensin 1 Gene Polymorphisms with Alopecia Areata Patients

Details

Type

Article

Created At

23 Jan 2023