Background: A successful endodontic treatment depends on several factors, however the most important
objective is to achieve a tridimensional RC obturation to provide optimal coronal and apical seal, and entomb
the remaining bacteria. Aim of the Study: to evaluate the solubility of a newly introduced BC sealer
(CeraSeal) compared to those of MTA-Fillapex, and Adseal. Materials and Methods: Twenty-four sealer
discs were prepared and incubated until complete setting of the sealers. The discs were divided into three
groups according to the sealer's type and then weighed using a precision balance to 0.0001 g. Then they
were immersed in HBSS at 37°C. At 1, 7, 14, 21, and 27 days intervals, the discs were removed from the
containers and dried, reweighed, and then re-immersed in a new HBSS. Solubility was calculated as
percentage of mass loss. Results were tabulated and statistically analyzed. Results: there was a statistically
significant difference in the solubility of the three sealers with MTA-Fillapex showing the highest solubility
at all times except after 24 hours where CeraSeal had higher solubility. All sealers showed progressively
increasing dissolution over time reaching maximum solubility values at day (27). Both MTA-Fillapex and
CeraSeal had solubility values which exceeded that recommended by the ISO specification No. 6876:2012
(i.e., 3%). Conclusion: Resin-based sealers outperformed CSBSs in terms of solubility dentin. CSBSs'
solubility violated the set range by the ISO specification NO. 6876:2012 (3% mass fraction).