Abstract: Introduction: Activation of sodium hypochlorite irrigation has proven to be very successful in the eradication of microorganisms, Laser activated irrigation is a new method of activation that has proven to be useful in the achievement of proper periapical healing. Aim of the study: To assess the efficiency of diode laser-activated on the healing of periapical tissues. Materials and subjects: 24 patients received single visit endodontic treatment, they were divided into 2 equal groups, Group I received Laser activated irrigation during endodontic treatment and Group II served as a control with a mock laser. CBCT was taken before commencing treatment and after 12 months of the treatment, linear calculations on CBCT were assessed. Results: indicated that pair-wise comparisons between the groups revealed that there was no statistically significant difference between laser-activated irrigation and conventional root canal treatment Conclusion: Laser activated irrigation is similar to conventional irrigation protocol using sodium hypochlorite