Infectious bursal disease (IBD) is caused by infectious bursal disease virus (IBDV) belonging to the family Birnaviridae. This virus causes an immunosuppressive disease in chickens. In case of subclinical infection of IBDV in young birds less than 3 weeks causes permanent immunosuppression. The current study aims to genetically characterize the IBDVs collected from 6 different governorates in Egypt within 2020 -2021. The forty samples were extracted and tested by RT-PCR for IBDV.  The positive samples amplicons were purified and sequenced. The analysis included the alignment of the deduced amino acids and phylogenetic tree. The study revealed that the circulating IBDV strains include genotype A3 of the very virulent IBDV ( vvIBDV ). The comparison between the sequenced samples and the available IBD vaccines showed mutations in the antigenic sites of P domain loops. So it is important to evaluate the immunogenicity and the efficiency of the current used vaccines to select the most appropriate one. However, the selection of a seed virus from the circulating IBDV is considered the best choice after comprehensive surveillance.