Contamination of poultry feed by heavy metals represents a risk to human health as they bioconcentrates in the food chain. As probiotics are worldwide distributed in many different products and with proven benefits to both human and animal health. This study is designed to investigate the role of the probiotic; Bactozyme; to overcome contamination of broiler feed by heavy metals. Forty chicks at age of 20 days were divided into 4groups; 1^st group served as control, 2^nd group was administered with 0.5 gm Bactozyme/ liter water; 3^rd group received contaminated feed with heavy metals, and 4^th group received both contaminated feed and Bactozyme. All chickens were sacrificed at the day 40^th of age. Sera were collected from all groups to determine liver and kidney function tests, samples from liver, kidney and muscles were collected and preserved at -20°C for residual detection of heavy metals using Atomic Absorption Spectrometry.
The results showed that feeding broilers on heavy metals contaminated diet led to significant increase of liver enzymes (AST, ALT& ALP), significant decrease of total protein, globulin, and significant increase of creatinine while albumin is insignificantly decreased. Residues of lead, cadmium and arsenic were significantly increased in all examined tissues. The groups received bactozyme with/ without heavy metals contaminated feed showed improvement of all tested parameters that strengthen the hypothesis of efficiency of probiotics to tolerate heavy metals toxicity in broilers.