A significant risk factor for cardiovascular illnesses is hypercholesterolemia. In traditional medicine, seeds like celery, coriander, and purslane are well-known for their medicinal properties. This research sought to determine how celery, coriander, and purslane affected hypercholesterolemic rats. 42 male albino rats were divided into seven groups with six animals each for 60 days: negative control fed on a basal diet, positive control hypercholesterolemic rats were fed on a basal diet +1% cholesterol. Four group fed as positive control with 20% of celery, coriander, purslane and mixture of seeds. The last group demonstration oral drug rosuvastatin (10 mg/kg/day). The present study showed that hypercholesterolemia caused significantly increases in body weight gain, food intake and FER as well as total cholesterol (TC), total triglycerides (TG), low density lipoprotein (LDL-c), very low density lipoprotein (VLDL-c), total lipid, phospholipid, urea, creatinine, total protein, albumin, globulin and MDA and decrease in and high density lipoprotein (HDL-c), GSH and SOD in positive control. Supplemented diet of hypercholesterolemic rats with seeds, especially (20% mixture of seeds) lead to significant (p˂0.05) decrease in body weight gain, food intake and FER as well as total cholesterol (TC), total triglycerides (TG), low density lipoprotein (LDL-c), very low density lipoprotein (VLDL-c), total lipid, phospholipid, urea, creatinine, total protein, albumin, globulin and MDA and significant increase of HDL, GSH and SOD comparing with negative control. Our findings suggested that the supplementation diet with celery, coriander and purslane seeds caused obvious reduction in lipid levels in a hypercholesterolemia disease