Red chilli was irradiated with two types of radiations; gamma and microwave. The effects of gamma and microwave technology on the anticarcinogenic properties of red chilli and its possible use as a helpful agent in the treatment of cancer were investigated. Biochemical studies indicated that the carcinogenic effect of 1,2-dimethylhydrazine (DMH) treatment was significantly modulated on red chilli supplementation as indicated by the observed significant changes of serum levels of vascular endothelial growth factor (VEGF) and Tissue inhibitors of metalloproteinases-1 (TIMP-1) particularly with gamma irradiated red chilli. The results of this study suggested that red chilli had a beneficial effect on chemically induced cancer in rats. The study might provide an effective dietary chemopreventive approach to disease management.   Keywords: Red chilli, DMH, VEGF, TIMP-1