Abstract Forty-two adult male of Sprague Dawley strain rats classified into control (-ve) group and five rat groups which administered 2 g/kg paracetamol by stomach tube to induced liver necrosis. One of them served as control (+ve) rat group while the others were physalis powder, physalis juice, aqua physalis extract and methanol physalis extract treated rat groups. The study assigned for eight weeks. The results showed that control (+ve) rat group showed a significant decrease in final weight, weight gain , food efficiency ratio(FER) , food intake , serum high denisity lipoprotein cholesterol (HDLc) ,liver glutathione peroxidase (GPX), superoxide dismutase (SOD) , catalase, triglyceride and glycogen. On the hand, it showed a significant increase in serum cholesterol, triglyceride, low denisity lipoprotein cholesterol (LDLc), very low denisity lipoprotein cholesterol (VLDLc), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and cholesterol/HDLc ratio. These changes were accompanied by an increase in liver malondialdehyde (MDA), cholesterol and total lipids compared to control (-ve) group. Both physalis powder and physalis juice treated groups showed a significant decrease in final weight, weight gain , FER, liver catalase and glycogen but showed a significant increase in liver MDA and  total lipids compared to control (- ve) group. Physalis powder, physalis juice, aqua physalis extract and methanol physalis extract treated groups showed a significant increase in cholesterol/HDLc ratio, serum LDLc, ALT, AST , ALP ,LDH and liver MDA and a significant decrease in liver GPX and SOD compared to control (-ve) group. It is concluded that consumption of physalis can reduce liver damage in the experimental rats. Key words: paracetamol – physalis- physalis extract-rats.