Abstract The present study was performed to evaluate the effect of wheat germ and fermented wheat germ on some Immunoglobulin's productions , lipids profile and liver functions  in cirrhotic rats by Ccl4 . Rats were divided into eight groups , control groups (1&2)  negative and positive were fed on basal diet without supplementation.  All treated cirrhotic groups  (3:8 ) were fed on experimental diets with raw or fermented wheat germ by different levels ( 5, 10 &15%) . Results clearly revealed that fermented wheat germ recorded the highest values in Vitamin (A), (E) and (C), comparing with raw wheat germ . The best treatment were fermented wheat germ (15%) and raw wheat germ (15% ) which had lowest values of total lipid , triglycerides , total cholesterol  LDL , VLDL , AST , ALT  and had the highest values of HDL ,  respectively. While , all groups administrated fermented wheat germ by different levels (5, 10,15%) had the highest values of serum level of interferon gamma (INF-y) and interleukin -10 (IL-10) respectively . It could be concluded that wheat germ and fermented wheat germ improve some Immunoglobulin's production , lipids profile and liver functions especially fermented wheat germ 10 and 15% which has a best significant protective effect against acute hepatotoxicity induced by CCl4  in rats. Key Word: fermented wheat germ – cirrhosis – CCl4 – liver oxidative
stress - immune .