Abstract The present study aimed to investigate the effect of different concentrations from Mulberry leaves of rats suffering from diabetes. Twenty male Albino rats Sprague Dawley strain weighing (140±10g) injected with (150mg) alloxan /Kg b.w) to induce diabetic. they divided into four groups one of them fed on basil diet as positive control group, the other group fed on basil diet and treated orally daily with different concentration from Mulberry leaves 10,15,20%  for five weeks . Sensory evaluation was three food items by 10 non-dependent diabetes people, also biological evaluation and estimating the biochemical analysis for liver function, kidney function, and blood glucose, as well as blood glucose was analyzed daily to all samples throughout the experiment period. The mean value of serum glucose of rats were significant, uric acid values of all groups were also significant.  the mean values of serum GOT, GPT and alkaline phosphates for all groups were lower than the control .The mean values of BWG. For all rats were significant as compared with the control group. Concluded from the above that the Mulberry leaves by the different average 10,15, 20% led to a significant decrease in blood glucose, and recommend using Mulberry leaves  a  remedy for patients with diabetes non-dependent.