Abstract Work was conducted to study the health and possible therapeutic effects of popular and less famous herbs on serum glucose and side effects of diabetes mellitus in alloxan injected rats. Sixty five mature male albino rats weighing 130-200g each divided into 13 groups (5 rats each) one kept as control (-) group while other 12 groups injected with alloxan. Herbs added at 7.5% to the basal diet given single or with bitter wood , bitter apple , harmala , garden cress , Dr.Mings tea and the mixture of them when unsupplemented or supplemented with wild Zommair and horse chestnut. Serum liver enzymes (ALT, AST, ALP), serum protein fractions(T.P, Alb, Glob & A/G), serum lipids (TC, TG, HDL, LDL, VLDL& atherogenic index''A.I''), serum creatinine, urea, uric acid, serum glucose as well as body weight gain(BWG), feed intake(FI) and feed efficiency ratio(FER)were recorded. The feeding trial continued for 28 days. The obtained results revealed that all herbs used were of value for amelioration of diabetes mellitus and its side effects provided that the collection of them showed best results.