Abstract Aim: Evalute the effect of three weight reduction(WT) systems of obese adults through one of the three systems [nutrition, or nutrition & exercise, or surgery] on serum lipids (cholesterol and triglycerides) and blood pressure level in obese patients. Patients& Methods: 90 obese male or female individuals (weight increases 20% of ideal weight) from Assiut University Hospitals, and follow methods for weight reduction. Their ages ranged from 25-55 years, they did not have any chronic diseases like( diabetes, high blood pressure, heart diseases). They were submitted to socioeconomic history taking, clinical, and laboratory investigations. They were equally devided to three  groups as follow: group(1): 30 patients  follow the nutritional system only for weight reduction : 17 females 13 males. (2): 30 patients follow the nutritional system beside practicing exercises for weight reduction: 21 females 9 males. (3): 30 patients were treated surgically by liposuction or lipectomy or both: 30 females. Statistical analysis and nutrition education were applied. The sample included 56 individuals from urban and 34 individuals from rural who are coming from different five villages (Abnob, Manfalot, Aboteeg, Albadary, Alfath. Results: It has been revealed that mean level of total cholesterol (chol) was significantly reduced in the  all groups post (WT) reduction program at (P<0.01). The Hemoglobin (Hgb) was significantly increased post (WT) reduction program in nutrition and nutrition & exercise groups respectively at (P<0.01) but in surgery group was significantly reduced at (P<0.01) . While mean glucose was significantly decreased in nutrition and nutrition & exercise groups respectively post (WT) reduction program at (P<0.05), but in surgery group was significantly increased at (P<0.05). The three systems for (WT) reduction decreased the blood pressure.