ABSTRACT The present work aimed to evaluate the effect of Almond  nut, Sambucus herbs, Juniperus seeds, Grapefruit albedo & the combination of all(as5%) on reinopathic rats. For this purpose , the study included about 35 rats about 150/200(g) weight. Biological & chemical analysis of serum and histopathological investigation of internal organs were carried out. The experiment lasted for 4 weeks and eventually urine samples were collected for each rat for 24 hours and  size measwredand  estimated (creatinine - urea - uric acid - protein - sodium - potassium). The weight of the rats and collect blood samples after collected fasting 12 hours and then serum separated to estimation of (creatinine - urea - uric acid – lipid profile - sodium - potassium - GPT-ALP-GOT). The weight  of the internal organs (liver - kidney - heart - spleen - lung) determined and fixed in 10% formalin for histopathological examinations. finally a statistical analysis of all the data and was done.