Abstract
Objective: The purpose of present study was to investigate the protective efficacy of star anise seed (SAS) on oxidative stress induced by cadmium in rats.
Methods: Thirty five of white male albino rats were divided to 5 groups: negative, CdCl2 (5mg/kg b.w) control, CdCl2 + SAS (50g/kg diet), CdCl2 + SAS (100g/kg diet) and CdCl2 + SAS (150 g/kg diet). The rats were feeding on star anise seeds daily for a period of 6 weeks. The variation in lipid profile, the biomarkers of liver and renal function, lipidperoxidation , SOD, total antioxidant capacity and acetylcholinesterase concentration were studied. As well as, histological assay of liver, kidney and brain in rats.
Result: Cadmium toxicity induces significant increase in serum lipid profile parameters except HLDL-C, ALT, AST, urea, creatinine, uric acid, MDA, AChE levels. Moreover, significant decrease in body weight gain, HLDL-C, SOD and total antioxidant capacity. Results of the histological examination of liver, renal and brain also support the above findings.
Conclusion: The current study suggests that star anise seed powder may be beneficial with promising prospect as a preventative antioxidant agent to resist oxidative damages induced by cadmium in rats.
Keywords: Star anise, cadmium chloride; oxidative stress; acetylcholinesterase; lipid peroxidation