Abstract The main objective of this study is to Evaluating nutritional status of children with Cancer (Acute lymphoblastic leukemia - Acute myeloid leukemia) using tube Feeding. The study included 36 Egyptian children diagnosed ALL and AML which is the most common form of childhood cancer leukemia. The study continued for two months. All children were matched for age (6.92+1.05) content of 50% boys and 50% girls. Data were collected about Anthropometric measurements, nutritional status and medical tests. The results showed that BMI were indicated normal status and nutritional status score was even more than 100% of Reference Range. for ALL and AML cases. Hb & Lymphoblast were higher in AML than ALL. No difference found in the result between ALT and AST. Urea level of AML and ALL Children were in high level, but AML children were more than the upper limit of the Reference Range. The food intakes in the hospital compared with DRI were more than 100% while the other nutrients were less than DRI, deficiency was particularly evident for selenium (72.14% of DRI), followed by Vit.A (75.75% of DRI) and Vit.C (80.80% of DRI) . Key Words: Acute lymphoblastic leukemia - Acute myeloid leukemia -Tube feeding- Dietary Reference Intakes .