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THE EFFECT OF SOME LEVELS OF FENNEL SEEDS AGAINST TRAMADOL TOXICITY INDUCED OXIDATIVE STRESS IN RATS

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Last updated: 04 Jan 2025

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الاقتصاد المنزلي

Abstract

Abstract The main objective of this study was to investigate the effectof fennel (Foeniculum Vulgare) seeds on  serum parameters including kidney functions, liver enzymes, lipid profiles, malondialdehyde, superoxide dismutase (SOD), acetycholinesterase activities, total antioxidants and blood hemoglobin for Tramadol  toxicity induced in rats. The experiment was carried out using thirty male albino rats weighing 145±5g. After the acclimatization period, rats were divided randomly into two main groups, the first main group (n= 6 rats) fed on the basal diet only as a negative control (normal group). The second main group (n= 24 rats) were oral with tramadol hydrochloride at dose of (200 mg/kg bw.) to induce tramadol toxicity. The second main group (oral with tramadol) divided into 4 subgroups (each 6 rats) as follow: Subgroup (1): was kept without any treatment as a positive control (+ve group) and fed on basal diet. Subgroups (2, 3 &4): were fed on basal diet containing 10%, 20% & 30 fennel seeds powder, respectively. Results indicated that,oral rats with tramadol increased. significantly all the previous parameters, except FI, BWG %, high density lipoprotein, superoxide dismutase (SOD) activity, total antioxidants and blood hemoglobin showed significant decrease compeded with all treated with levels of fennel seeds powder. The present study recommended that consuming fennel seeds improved the symptoms of tramadol toxicity and prevent its complications.

DOI

10.21608/mbse.2018.137712

Authors

First Name

Samah

Last Name

A. Elsemelawy

MiddleName

-

Affiliation

Home Economics Dept., Faculty of Specific Education, Tanta University, Egypt

Email

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City

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Orcid

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First Name

El-Nahas

Last Name

O.I.

MiddleName

-

Affiliation

Home Economics Dept., Faculty of Specific Education, Mansoura University, Egypt

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-

City

-

Orcid

-

Volume

2018

Article Issue

49

Related Issue

20262

Issue Date

2018-01-01

Receive Date

2017-12-07

Publish Date

2018-01-01

Page Start

35

Page End

52

Print ISSN

2314-8683

Online ISSN

2314-8691

Article File

MBSE_Volume 2018_Issue 49_Pages 35-52.pdf

PDF . 226.0kB

Link

https://mbse.journals.ekb.eg/article_137712.html

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https://mbse.journals.ekb.eg/service?article_code=137712

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3

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مقالات علمیة محکمة

Type Code

1,632

Publication Type

Journal

Publication Title

مجلة بحوث التربية النوعية

Publication Link

https://mbse.journals.ekb.eg/

MainTitle

THE EFFECT OF SOME LEVELS OF FENNEL SEEDS AGAINST TRAMADOL TOXICITY INDUCED OXIDATIVE STRESS IN RATS

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Article

Created At

23 Jan 2023