Background: Recreational program is a distinct professional field that focuses on ways to incorporate physical and intellectual activities into a structured program to improve cognitive, emotional functioning and well-being. Aim of this study: Was to evaluate effect of recreational program on psychological status of children with cancer at pre therapeutic procedure. Design: Quasi-experimental design (pre-test, post-test) was utilized to achieve the aim of this study. Setting: This study was conducted at National Cancer Institute in Cairo for pre therapeutic cancer children. Study sample: A convenient sample of 60 children attending for pre therapeutic procedure before receiving drug dose. Data collection tools: Four tools were used: Tool (1): Structured interviewing questionnaire divided in two parts, I: Socio demographic data, II: Knowledge of children about recreational program, Tool (2): The Spence Children's Anxiety Scale (SCAS), Tool (3): Hamilton Scale of Depression scale & Tool (4): White perceived stress scale. Results: The result showed there were highly statistically significant difference between total knowledge of children regarding recreational program post compared to pre-educational program implementation p<0.001. There was highly statistically significant improvement of psychological problems(depression, anxiety, stress) post program compared to preprogram implementation. Conclusion: The recreational intervention program had a positive effect on reducing the psychological problems among pre therapeutic procedure cancer children. Recommendations: Recreational program should apply to decrease the level of negative emotion in patients (children) with cancer.